Zonisamide approved for partial seizures
نویسندگان
چکیده
منابع مشابه
Update on once-daily zonisamide monotherapy in partial seizures
Zonisamide is an antiepileptic drug that is structurally different from other antiepileptic agents. Its long half-life, once-daily dosing, lack of induction of hepatic enzymes, and broad spectrum of action makes it a suitable candidate for monotherapy. It has been approved as monotherapy for partial onset epilepsy in Japan and South Korea for more than a decade, and was recently approved as mon...
متن کاملZonisamide – a review of experience and use in partial seizures
Zonisamide is a modern antiepileptic drug (AED) that is distinguished from other AEDs by its unique structure and broad mechanistic profile. Preclinical studies have reported a range of potential mechanisms of action for zonisamide, such as blocking voltage-gated sodium channels, reduction of T-type calcium channel currents, and enhancement of gamma-aminobutyric acid (GABA)-mediated inhibition,...
متن کاملProfile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults
Epilepsy is one of the most common neurologic disorders, affecting about 50 million people around the world. It is recognized that around 50% of patients with newly diagnosed epilepsy become seizure-free with the first drug treatment, so the choice of first antiepileptic drug is crucial. This paper provides a comprehensive overview of zonisamide as monotherapy for partial seizures, with special...
متن کاملPilot study of zonisamide (1,2-benzisoxazole-3-methanesulfonamide) in patients with refractory partial seizures.
A new anticonvulsant compound, zonisamide (1,2 benzisoxazole-methanesulfonamide), was studied in 10 adults with medically refractory partial seizures. Following a single oral dose of 400 mg, peak plasma levels occurred an average of 2.8 h after dosing, and the mean clearance from plasma was 2.34 L/h. Whole blood concentrations were higher than plasma concentrations because of red blood cell bin...
متن کاملZonisamide for seizures in Parkinson's disease with dementia
Zonisamide (ZNS) is a sulphonamide antiepileptic drug (AED) used to treat epilepsy around the world. Recent studies suggested that ZNS is an effective treatment for motor and nonmotor symptoms of Parkinson’s disease (PD) (for a review). However, only one randomized, double-blind, multicentre, placebo-controlled study conducted in Japan demonstrated the efficacy of ZNS as add-on administration i...
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ژورنال
عنوان ژورنال: American Journal of Health-System Pharmacy
سال: 2000
ISSN: 1079-2082,1535-2900
DOI: 10.1093/ajhp/57.9.834a